Prohibitin 1 suppresses liver cancer tumorigenesis in mice and human hepatocellular and cholangiocarcinoma cells.

Wei FanHeping YangTing LiuJiaohong WangTony W H LiNirmala MavilaYuanyuan TangJinWon YangHui PengJian TuAlagappan AnnamalaiMazen NoureddinAnuradha KrishnanGregory J GoresMaria L Martínez-ChantarJosé M MatoShelly C Lu

Published in: Hepatology (Baltimore, Md.) (2017)

We have identified that PHB1, down-regulated in most human HCC and CCA, heterodimerizes with MAX to repress the E-box and positively regulates MAT1A while suppressing c-MYC, MAFG, and c-MAF expression; in mice, reduced PHB1 expression predisposes to the development of cholestasis-induced CCA. (Hepatology 2017;65:1249-1266).

Keyphrases

endothelial cells
poor prognosis
transcription factor
binding protein
high glucose
signaling pathway
induced apoptosis
induced pluripotent stem cells
high fat diet induced
pluripotent stem cells
drug induced
cell cycle arrest
metabolic syndrome
long non coding rna
diabetic rats
cell death
insulin resistance