MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.

Hui TangDi FanChun-Tao LeiChen YePan GaoShan ChenXian-Fang MengHua SuChun Zhang

Published in: Journal of molecular medicine (Berlin, Germany) (2016)

Renal fibrosis activates MAD2B expression in renal tubules of human and mouse. TGF-β1 contributes to MAD2B enhancement in rat tubular epithelial cells. MAD2B depletion alleviates renal tubulointerstitial fibrosis in vivo and in vitro. MAD2B promotes EMT transition in rat tubular epithelial cells by inducing Skp2.

Keyphrases

endothelial cells
poor prognosis
oxidative stress
epithelial mesenchymal transition
liver fibrosis
long non coding rna
diabetic nephropathy
pluripotent stem cells