Effects of aerobic and inspiratory training on skeletal muscle microRNA-1 and downstream-associated pathways in patients with heart failure.
Ligia M Antunes-CorreaPatricia F TrevizanAline V N BacurauLarissa Ferreira-SantosJoão L P GomesUrsula UriasPatricia A OliveiraMaria Janieire N N AlvesDirceu R de AlmeidaPatricia C BrumEdilamar M OliveiraLudhmila HajjarRoberto Kalil FilhoCarlos Eduardo NegrãoPublished in: Journal of cachexia, sarcopenia and muscle (2019)
AET upregulates microRNA-1 levels and decreases the protein expression of PTEN, which reduces the inhibitory action on the PI3K-AKT pathway that regulates the skeletal muscle tropism. The increased levels of microRNA-1 also decreased HDAC4 and increased MEF2c, MyoD, and follistatin expression, improving skeletal muscle regeneration. These changes associated with the increase in muscle cross-sectional area and LBF contribute to the attenuation in skeletal myopathy, and the improvement in functional capacity and quality of life in patients with HFrEF. IMT caused no changes in microRNA-1 and in the downstream-associated pathway. The increased functional capacity provoked by IMT seems to be associated with amelioration in the respiratory function instead of changes in skeletal muscle. ClinicalTrials.gov (Identifier: NCT01747395).