Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells.

Shiqi XiangZhong LiMadalyn R FritchLa LiSachin VelankarYuwei LiuJihee SohnNatasha BakerHang LinRocky S Tuan

Published in: Stem cell research & therapy (2021)

Soft biomaterials support superior adipogenesis of encapsulated hBMSCs in 3D culture, which is partially mediated by the CAV1-YAP axis. Suppressing CAV1 expression levels represents a robust method in the promotion of hBMSC adipogenesis.

Keyphrases

mesenchymal stem cells
high fat diet induced
endothelial cells
poor prognosis
tissue engineering
signaling pathway
umbilical cord
induced pluripotent stem cells
pluripotent stem cells
type diabetes
metabolic syndrome
insulin resistance
stem cells
cell therapy
adipose tissue
skeletal muscle