Alpha-Asarone modulates kynurenine disposal in muscle and mediates resilience to stress-induced depression via PGC-1α induction.
Lu YanChu-Han LiuLi XuYi-Yun QianPing-Ping SongMin WeiBao-Lin Liu
Published in: CNS neuroscience & therapeutics (2022)
KATs coupled with MAS to clear KYN in muscle. α-Asarone increased PGC-1α induction and promoted KYN disposal in muscle, suggesting that protection of mitochondria is a way for pharmacological intervention to depression.