Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice.
Amandine ChaixTerry LinBastian RammsRoy G CutlerTiffani LeCatherine LopezPhuong MiuAntonio F M PintoAlan SaghatelianMartin P PlayfordNehal N MehtaMark P MattsonPhilip L S M GordtsJoseph L WitztumSatchidananda PandaPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
In a preclinical animal model, TRF is effective in both the prevention and regression of atherosclerosis in LDLR knockout mice. The results suggest TRF alone or in combination with a low-cholesterol diet can be a lifestyle intervention for reducing cardiovascular disease risk in humans.
Keyphrases
- cardiovascular disease
- low density lipoprotein
- randomized controlled trial
- weight loss
- physical activity
- type diabetes
- cardiovascular events
- cardiovascular risk factors
- cognitive decline
- high fat diet induced
- high fat diet
- cell therapy
- metabolic syndrome
- stem cells
- adipose tissue
- insulin resistance
- coronary artery disease
- wild type