Protease inhibitors targeting the main protease and papain-like protease of coronaviruses.
Clemente CapassoAlessio NocentiniClaudiu T SupuranPublished in: Expert opinion on therapeutic patents (2020)
The X-ray crystal structures of some of these proteases, alone and in complex with various inhibitors, were crucial for the discovery of effective such compounds, some of which also showed considerable antiviral activity and are considered preclinical candidates to fight these emerging infections, which in the case of Covid-19 already provoked an unprecedented worldwide pandemic.