RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression.

Yanyan WangYun-Ling TaiGrayson WayJing ZengDerrick ZhaoLianyong SuXixian JiangKaitlyn G JacksonXuan WangEmily C GurleyJinze LiuJinpeng LiuWeidong ChenXiang-Yang WangArun J SanyalPhillip B HylemonHuiping Zhou

Published in: Cell & bioscience (2022)

HuR not only functions as an RNA binding protein to modulate post-transcriptional gene expression but also regulates H19 promoter activity. Hepatic HuR is an important regulator of hepatic lipid metabolism via modulating H19 expression.

Keyphrases

binding protein
gene expression
long noncoding rna
transcription factor
dna methylation
poor prognosis
signaling pathway
nucleic acid
fatty acid