Biological and clinical impact of membrane EGFR expression in a subgroup of OC patients from the phase IV ovarian cancer MITO-16A/MANGO-OV2A trial.

Luca ForlaniLoris De CeccoVittorio SimeonBiagio PaoliniMarina BagnoliSabrina Chiara CecereAnna SpinaEleonora CiteroniEliana BignottiDomenica LorussoLaura ArenareDaniela RussoCarmine De AngelisLaura ArdighieriGiosuè ScognamiglioMichele Del SestoGermana TognonDaniela CalifanoClorinda SchettinoPaolo ChiodiniFrancesco PerroneDelia MezzanzanicaSandro PignataAntonella Tomassetti

Published in: Journal of experimental & clinical cancer research : CR (2023)

Strong and homogeneous cell membrane localization of EGFR, associated with specific transcriptional traits, can be considered a prognostic biomarker in OC patients and could be useful for a better OC patients' stratification and the identification of alternative therapeutic target/s in a personalized therapeutic approach.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
small cell lung cancer
prognostic factors
gene expression
poor prognosis
randomized controlled trial
genome wide
epidermal growth factor receptor
oxidative stress
patient reported outcomes
binding protein
long non coding rna