BurkHostGEN: a study protocol for evaluating variations in the Burkholderia pseudomallei and host genomes associated with melioidosis infection.

Kesorn AngchagunPhumrapee Boonklang Chalita ChomkatekaewSukritpong PakdeeratGumphol WongsuwanPremjit AmornchaiVanaporn WuthiekanunSalwaluk PanapipatThatsanun Ngernseng Naomi WaithiraSteve WaltonDirek LimmathurotsakulAnoree SurawongSuwatthiya SiriboonParinya ChamnanNarisara ChantratitaSusanna J Dunachie Jukka CoranderEmma E DavenportJulian KnightJulian ParkhillSharon J PeacockNicholas R ThomsonNicholas Philip John DayClaire Chewapreecha

Published in: Wellcome open research (2023)

BurkHostGEN holds the potential to discover bacterial and host genetic factors associated with melioidosis infection and severity of illness. It can also support various study designs, including biomarker validation, disease pathogenesis, and epidemiological analysis not only for melioidosis but also for other infectious diseases.

Keyphrases

infectious diseases
risk assessment
human health
copy number
dna methylation
data analysis