Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer.
Ayat Gamal LashenMichael S TossLouisa WoottonAndrew R GreenNigel Patrick MonganMadhusudhan SrinivasanEmad A RakhaPublished in: Histopathology (2023)
The prognostic role of PLK1 in BC is molecular subtype-dependent. As PLK1 inhibitors are introduced to clinical trials for several cancer types, our study supports evaluation of the pharmacological inhibition of PLK1 as an attractive therapeutic target in TNBC. However, in luminal BC, PLK1 prognostic role remains controversial.