Differentiation of Mesenchymal Stem Cells Derived From Human Adipose Tissue Into Cholinergic-like Cells: An in Vitro Study.
Davood SanooghiNaser AminiFereshteh AzediZohreh BagherAsghar ParvishanAbolfazl LotfiNooshin RashidiErfan LotfiForough Azam SayahpourFaezeh FaghihiPublished in: Basic and clinical neuroscience (2021)
Human AD-MSCs are potent cells to differentiate into cholinergic-like cells in the presence of RA and Shh through a three-step protocol. Thus, they could be a suitable cell candidate for the regeneration of cholinergic-associated diseases. However, more functional and electrophysiological analyses are needed in this regard.
Keyphrases
- mesenchymal stem cells
- endothelial cells
- adipose tissue
- umbilical cord
- induced pluripotent stem cells
- stem cells
- induced apoptosis
- cell therapy
- rheumatoid arthritis
- randomized controlled trial
- pluripotent stem cells
- cell cycle arrest
- insulin resistance
- high fat diet
- oxidative stress
- type diabetes
- cell proliferation
- ankylosing spondylitis
- interstitial lung disease
- disease activity