CRISTAL: protocol for a cluster randomised, crossover, non-inferiority trial of aspirin compared to low molecular weight heparin for venous thromboembolism prophylaxis in hip or knee arthroplasty, a registry nested study.
Verinder Singh SidhuSteven E GravesRachelle BuchbinderJustine Maree NaylorNicole L PrattRichard S de SteigerBeng H ChongIlana N AckermanSam AdieAnthony HarrisAmber HansenMaggie CrippsMichelle LorimerSteve WebbOrnella ClavisiElizabeth C GriffithDurga AnandanGrace O'DonohueThu-Lan KellyIan A HarrisPublished in: BMJ open (2019)
Ethics approval has been granted. Trial results will be submitted for publication. The trial is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12618001879257, pre-results) and is endorsed by the Australia and New Zealand Musculoskeletal Clinical Trials Network.
Keyphrases
- clinical trial
- phase ii
- phase iii
- open label
- venous thromboembolism
- study protocol
- double blind
- placebo controlled
- randomized controlled trial
- public health
- low dose
- direct oral anticoagulants
- cardiovascular events
- coronary artery disease
- growth factor
- acute coronary syndrome
- percutaneous coronary intervention
- cardiovascular disease
- global health