Potential of heart fatty-acid binding protein, neurofilament light, interleukin-10 and S100 calcium-binding protein B in the acute diagnostics and severity assessment of traumatic brain injury.
Pia KoivikkoJussi P PostiMehrbod MohammadianLinnéa LagerstedtLeire AzurmendiIftakher HossainAri J KatilaDavid MenonVirginia F J NewcombePeter John HutchinsonHenna-Riikka MaanpääJussi TallusHenrik ZetterbergKaj BlennowOlli TenovuoJean-Charles SanchezRiikka S K TakalaPublished in: Emergency medicine journal : EMJ (2021)
S100B, H-FABP, NF-L and IL-10 levels in patients with mTBI were significantly lower than in patients with moTBI and sTBI but alone or in combination, were unable to distinguish patients with mTBI from orthopaedic controls. This suggests these biomarkers cannot be used alone to diagnose mTBI in trauma patients in the acute setting.
Keyphrases
- binding protein
- traumatic brain injury
- liver failure
- trauma patients
- mild traumatic brain injury
- respiratory failure
- fatty acid
- drug induced
- aortic dissection
- signaling pathway
- hepatitis b virus
- lps induced
- oxidative stress
- cerebrospinal fluid
- atrial fibrillation
- inflammatory response
- risk assessment
- pi k akt
- nuclear factor
- cell proliferation
- human health