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Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.

Michael H RadkeVictor Badillo-LisakowskiThiago Britto-BorgesDieter A KubliRené JüttnerPragati ParakkatJacobo Lopez CarballoJudith HüttemeisterMartin LissArne HansenChristoph DieterichAdam E MullickMichael Gotthardt
Published in: Science translational medicine (2021)
[Figure: see text].
Keyphrases
  • heart failure
  • left ventricular
  • endothelial cells
  • atrial fibrillation
  • blood pressure
  • pluripotent stem cells
  • smoking cessation
  • cardiac resynchronization therapy
  • acute heart failure
  • ejection fraction