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Restricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen.

Hyun Jin KwunMasahiro ShudaCarlos J CamachoArmin M GamperMamie ThantYuan ChangPatrick S Moore
Published in: Journal of virology (2015)
Merkel cell polyomavirus is a newly discovered human cancer virus that promotes cancer, in part, through expression of its small T (sT) oncoprotein. Animal polyomavirus sT oncoproteins have been found to cause experimental tumors by blocking the activities of a group of phosphatases called protein phosphatase 2A (PP2A). Our structural analysis reveals that MCV sT also displaces the B subunit of PP2A to inhibit PP2A activity. MCV sT, however, only displaces a restricted subset of PP2A B subunits, which is insufficient to cause tumor cell formation in vitro. MCV sT instead transforms tumor cells through another region called the large T stabilization domain. The PP2A targeting and transforming activities lie on opposite faces of the MCV sT molecule and can be genetically separated from each other.
Keyphrases
  • single cell
  • cell therapy
  • papillary thyroid
  • poor prognosis
  • stem cells
  • binding protein
  • protein kinase
  • protein protein
  • young adults
  • long non coding rna
  • mesenchymal stem cells
  • pluripotent stem cells