T cell expressions of aberrant gene signatures and Co-inhibitory receptors (Co-IRs) as predictors of renal damage and lupus disease activity.
Chin-Man WangYeong-Jian Jan WuJian-Wen ZhengLi Yu HuangKeng Poo TanJi-Yih ChenPublished in: Journal of biomedical science (2024)
The signature of dysfunctional pathways defines a distinct immunity pattern in LN ESRD patients. Expression levels of Co-IRs in peripheral blood T cells and serum levels of soluble PD1/PDL-2/TIM3 can serve as biomarkers for evaluating clinical parameters and therapeutic responses.
Keyphrases
- disease activity
- systemic lupus erythematosus
- end stage renal disease
- rheumatoid arthritis
- peripheral blood
- chronic kidney disease
- rheumatoid arthritis patients
- peritoneal dialysis
- ankylosing spondylitis
- newly diagnosed
- ejection fraction
- poor prognosis
- prognostic factors
- oxidative stress
- dna methylation
- patient reported outcomes