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Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice.

Shinichiro KawataAkinobu NakamuraHideaki MiyoshiKelaier YangIkumi ShigesawaYuki YamauchiKazuhisa TsuchidaKazuno OmoriKiyohiko TakahashiHiroshi NomotoHiraku KamedaKyu Yong ChoYasuo TerauchiTatsuya Atsumi
Published in: Diabetes, obesity & metabolism (2021)
The GKA showed an unsustained hypoglycaemic effect and promoted hepatic fat accumulation in db/db mice. Dynamic changes in the expression of hepatic genes involved in lipogenesis and gluconeogenesis could affect the unsustained hypoglycaemic effect of the GKA despite no changes in pancreatic β-cell function and mass.
Keyphrases
  • high fat diet induced
  • poor prognosis
  • adipose tissue
  • fatty acid
  • skeletal muscle
  • binding protein
  • wild type