Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice.
Shinichiro KawataAkinobu NakamuraHideaki MiyoshiKelaier YangIkumi ShigesawaYuki YamauchiKazuhisa TsuchidaKazuno OmoriKiyohiko TakahashiHiroshi NomotoHiraku KamedaKyu Yong ChoYasuo TerauchiTatsuya AtsumiPublished in: Diabetes, obesity & metabolism (2021)
The GKA showed an unsustained hypoglycaemic effect and promoted hepatic fat accumulation in db/db mice. Dynamic changes in the expression of hepatic genes involved in lipogenesis and gluconeogenesis could affect the unsustained hypoglycaemic effect of the GKA despite no changes in pancreatic β-cell function and mass.