Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities.
Jyoti S MathadSharan YadavArthi VaidyanathanAmita GuptaSylvia M LaCoursePublished in: Pathogens (Basel, Switzerland) (2022)
Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.
Keyphrases
- mycobacterium tuberculosis
- traumatic brain injury
- drug resistant
- pregnancy outcomes
- preterm birth
- severe traumatic brain injury
- pulmonary tuberculosis
- multidrug resistant
- pregnant women
- mild traumatic brain injury
- risk factors
- healthcare
- randomized controlled trial
- emergency department
- clinical trial
- adipose tissue
- insulin resistance
- adverse drug
- double blind
- placebo controlled