Syntenin-1-mediated arthritogenicity is advanced by reprogramming RA metabolic macrophages and Th1 cells.

Anja MeyerRyan E SienesWes NijimBrian ZanottiSadiq UmarMichael V VolinKatrien Van RaemdonckMyles J Lewis Costantino PitzalisShiva AramiMina Al-AwqatiHuan J ChangPim JetanalinLarissa Valor-MéndezNadera SweissShiva Shahrara

Published in: Annals of the rheumatic diseases (2023)

The syntenin-1/SDC-1 pathway plays a critical role in the inflammatory and metabolic landscape of RA through glycolytic MΦ and Th1 cell cross-regulation (graphical abstract).

Keyphrases

rheumatoid arthritis
single cell
induced apoptosis
disease activity
cell cycle arrest
oxidative stress
ankylosing spondylitis
cell therapy
endoplasmic reticulum stress
stem cells
cell death
signaling pathway
pi k akt