New drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi , the causative agent of Chagas disease.

Silvane Maria Fonseca MurtaPedro Augusto Lemos SantanaThibault Joseph William Jacques Dit LapierreAndré Berndt PenteadoMarissa El HajjeThabata Corazza Navarro VinhaDaniel Barbosa LiarteMariana Laureano de SouzaGustavo Henrique Goulart TrossiniCelso de Oliveira Rezende JúniorRenata Barbosa de OliveiraRafaela Salgado Ferreira

Published in: Expert opinion on drug discovery (2024)

strains. The combination of compounds that inhibit different metabolic pathways of the parasite is an important strategy for developing a new chemotherapeutic protocol.

Keyphrases

trypanosoma cruzi
drug discovery
randomized controlled trial
escherichia coli
replacement therapy
smoking cessation
plasmodium falciparum