Evolutionary history of human colitis-associated colorectal cancer.
Ann-Marie BakerWilliam CrossKit CurtiusIbrahim Al BakirChang-Ho Ryan ChoiHayley Louise DavisDaniel TemkoSujata BiswasPierre MartinezMarc J WilliamsJames O LindsayRoger FeakinsRoser VegaStephen J HayesIan P M TomlinsonStuart A C McDonaldMorgan MoorghenAndrew SilverJames E EastNicholas A WrightLai Mun WangManuel Rodriguez-JustoMarnix JansenAilsa L HartSimon J LeedhamTrevor A GrahamPublished in: Gut (2018)
Evolutionary genomic analysis revealed precancer clones bearing extensive SNAs and CNAs, with progression to cancer involving a dramatic accrual of CNAs at HGD. Detection of the cancerised field is an encouraging prospect for surveillance, but punctuated evolution may limit the window for early detection.