Resolving the dark side of therapy-driven cancer cell death.
Eduardo BonavitaVictoria S PellySantiago ZelenayPublished in: The Journal of experimental medicine (2017)
In this issue of JEM, Sulciner et al. (https://doi.org/10.1084/jem.20170681) provide evidence that therapy-induced cancer cell death can, paradoxically, stimulate and accelerate the growth of surviving malignant cells by fueling tumor-promoting inflammation. Resolvins, a class of lipid mediators, counteract this effect, representing an attractive target for therapeutic intervention.
Keyphrases
- cell death
- cell cycle arrest
- papillary thyroid
- squamous cell
- induced apoptosis
- randomized controlled trial
- oxidative stress
- squamous cell carcinoma
- childhood cancer
- stem cells
- lymph node metastasis
- mesenchymal stem cells
- drug induced
- fatty acid
- high glucose
- signaling pathway
- bone marrow
- young adults
- replacement therapy