Statin treatment effectiveness and the SLCO1B1*5 reduced function genotype: Long-term outcomes in women and men.
Deniz TürkmenJane A H MasoliChia-Ling KuoJack BowdenDavid MelzerLuke C PillingPublished in: British journal of clinical pharmacology (2022)
In this large community sample of patients on commonly prescribed statins, the SLCO1B1*5 decreased function variant had much larger effects on cholesterol control and treatment duration in women than in men. Efforts to improve the effectiveness of statin therapy in women may need to include SLCO1B1*5 genotype-guided statin selection.
Keyphrases
- cardiovascular disease
- polycystic ovary syndrome
- randomized controlled trial
- coronary artery disease
- systematic review
- low density lipoprotein
- pregnancy outcomes
- end stage renal disease
- healthcare
- newly diagnosed
- mental health
- cervical cancer screening
- pregnant women
- stem cells
- breast cancer risk
- bone marrow
- quality improvement