Targeting epidermal growth factor receptor in paclitaxel-resistant human breast and lung cancer cells with upregulated glucose-6-phosphate dehydrogenase.
Hye-Young MinHo Jin LeeYoung-Ah SuhHonglan PeiHyukjin KwonHyun-Ji JangHye Jeong YunHyeong-Gon MoonHo-Young LeePublished in: British journal of cancer (2022)
EGFR signaling-mediated G6PD expression plays a pivotal role in paclitaxel resistance, highlighting the potential of targeting EGFR to overcome paclitaxel resistance in TNBC and NSCLC cells overexpressing G6PD.
Keyphrases
- epidermal growth factor receptor
- advanced non small cell lung cancer
- tyrosine kinase
- small cell lung cancer
- induced apoptosis
- endothelial cells
- cancer therapy
- poor prognosis
- cell cycle arrest
- chemotherapy induced
- induced pluripotent stem cells
- binding protein
- human health
- oxidative stress
- endoplasmic reticulum stress
- blood pressure
- metabolic syndrome
- pluripotent stem cells
- long non coding rna
- blood glucose
- cell proliferation
- skeletal muscle