Imprinted gene clusters are confined genomic regions containing genes with parent-of-origin-dependent transcriptional activity. In this issue of Genes & Development , Loftus and colleagues (pp. XXX-XXX) made use of an insightful combination of descriptive approaches, genetic manipulations, and epigenome-editing approaches to show that differences in nuclear topology precede the onset of imprinted expression at the Peg13-Kcnk9 locus. Furthermore, the investigators provide data in line with a model suggesting that parent-of-origin-specific topological differences could be responsible for parent-of-origin-specific enhancer activity and thus imprinted expression.
Keyphrases
- genome wide
- poor prognosis
- dna methylation
- copy number
- genome wide identification
- binding protein
- transcription factor
- crispr cas
- gene expression
- solid phase extraction
- genome wide analysis
- cross sectional
- electronic health record
- long non coding rna
- big data
- machine learning
- oxidative stress
- heat shock
- deep learning