Oxidative stress, redox status and surfactant metabolism in mechanically ventilated patients receiving different approaches to oxygen therapy (MecROX): An observational study protocol for mechanistic evaluation.
Ahilanandan DushianthanDaniel MartinPaul MounceyTasnin ShahidLamprini LamproAmelia Francis JohnsonVictoria GossAngelica CazleyWilliam HerbertWilliam B JonesMark LamondFlorence NeyroudKaren SalmonJulian LentaigneMagdalena MinnionMadhuri PanchalGrielof KosterHelen MoysesAnthony D PostleMartin FeelischMichael P W GrocottPublished in: NIHR open research (2024)
surfactant synthesis and breakdown (by hydrolysis and oxidation), oxidative stress and redox disequilibrium from sequential plasma and bronchial samples using an array of analytical platforms. We will compare conservative and usual oxygenation groups according to the amount of oxygen administered. Trial registration: ISRCTNISRCTN61929838, 27/03/2023 https://doi.org/10.1186/ISRCTN61929838.
Keyphrases
- oxidative stress
- dna damage
- electron transfer
- ischemia reperfusion injury
- diabetic rats
- intensive care unit
- induced apoptosis
- study protocol
- clinical trial
- acute respiratory distress syndrome
- hydrogen peroxide
- phase iii
- high throughput
- randomized controlled trial
- cross sectional
- anaerobic digestion
- signaling pathway
- extracorporeal membrane oxygenation
- heat shock
- high density
- single cell
- endoplasmic reticulum stress
- double blind