Ring trial of 2nd generation RT-QuIC diagnostic tests for sporadic CJD.

Christina D OrrúBradley R GrovemanAaron FoutzMatilde BongianniFranco CardoneNeil McKenzieAudrey CuleuxAnna PoleggiKatarina GrznarovaDaniela PerraMichele FioriniXiaoqin LiuAnna LadoganaMarco SbriccoliAndrew G HughsonStéphane HaïkAlison J GreenMichael D GeschwindMaurizio PocchiariJiri G SafarGianluigi Zanusso Byron Caughey

Published in: Annals of clinical and translational neurology (2021)

This second-generation RT-QuIC assay is highly transferrable, reproducible, and therefore robust for the diagnosis of sporadic Creutzfeldt-Jakob disease in clinical practice.

Keyphrases

clinical practice
late onset
amyotrophic lateral sclerosis
study protocol
phase iii
high throughput
clinical trial
phase ii
randomized controlled trial
open label