Obesity is associated with altered tumor metabolism in metastatic melanoma.
Andrew W HahnAshley V MenkDayana B RivadeneiraRyan C AugustinMingchu XuJun LiXiaogang WuAditya K MishraTuba Nur GideCamelia QuekYan ZangChristine N SpencerAlexander M MenziesCarrie R Daniel-MacDougallCourtney W HudgensTheodore Scott NowickiLauren E HayduMd Abdul Wadud KhanVancheswaran GopalakrishnanElizabeth M BurtonJared C MalkeJulie M SimonChantale BernatchezNagireddy PutluriScott E WoodmanVashisht Gopal Y NRenato A GuerrieriGrant M FischerJian WangKhalida M WaniJohn F ThompsonJeffrey E LeePatrick HwuNadim J AjamiJeffrey E GershenwaldGeorgina V LongRichard A ScolyerMichael T TetzlaffAlexander J F LazarDirk SchadendorfJennifer A WargoJoanne M JeterRalph J DeBerardinisHan LiangP Andrew FutrealJianhua ZhangJames S WilmottWeiyi PengMichael A DaviesGreg M DelgoffeYana G NajjarJennifer Leigh McQuadePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
These findings suggest that the host metabolic phenotype influences melanoma metabolism and provide insight into the improved outcomes observed in OW/OB patients with metastatic melanoma treated with ICIs and targeted therapies.