Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy.
Shoichi FukuiHideki NakamuraYoshiko TakahashiNaoki IwamotoHiroo HasegawaKatsunori YanagiharaTatsufumi NakamuraAkihiko OkayamaAtsushi KawakamiPublished in: BMC immunology (2017)
In vitro, TNFi did not affect the cytokine profiles, expression of associated genes and proteins, proviral load or apoptosis of HCT-5 cells. The results suggested that TNFi treatment of RA patients complicated with HTLV-I might have no effect on HTLV-I infection.
Keyphrases
- cell cycle arrest
- rheumatoid arthritis
- induced apoptosis
- cell death
- end stage renal disease
- ejection fraction
- poor prognosis
- newly diagnosed
- endothelial cells
- endoplasmic reticulum stress
- spinal cord
- pi k akt
- oxidative stress
- prognostic factors
- patient reported outcomes
- cell proliferation
- signaling pathway
- gene expression
- spinal cord injury
- pluripotent stem cells
- induced pluripotent stem cells
- systemic lupus erythematosus