Adipose Dysfunction in Adulthood Insulin Resistance of Low-Birth Weight Mice: A Proteomics Study.
Jun WangLinlin YangLinquan YangFei ZhouHang ZhaoJing LiuHui-Juan MaGuangyao SongPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2022)
When exposed to high-fat diets, LBW mice exhibited insulin resistance and disorder of lipid metabolism compared with NBW mice. The expression of PPARγ was elevated, as well as upstream CD36, downstream SCD1 and PCK1 of the PPARγ in the adipose tissue of LBW mice. It was suggested that the activation in CD36/PPARγ/SCD1 and CD36/PPARγ/PCK1 pathways may induce adipose dysfunction, thereby increasing susceptibility to insulin resistance.
Keyphrases
- insulin resistance
- high fat diet induced
- adipose tissue
- high fat diet
- metabolic syndrome
- skeletal muscle
- polycystic ovary syndrome
- low birth weight
- type diabetes
- preterm infants
- oxidative stress
- mass spectrometry
- poor prognosis
- depressive symptoms
- preterm birth
- weight loss
- glycemic control
- human milk
- fatty acid
- label free
- long non coding rna
- binding protein