Bile Acid Profiling Reveals Distinct Signatures in Undernourished Children with Environmental Enteric Dysfunction.

Xueheng ZhaoKenneth D R SetchellRong HuangIndika MallawaarachchiLubaina EhsanEdward Dobrzykowski IiiJunfang ZhaoSana SyedJennie Z MaNajeeha T IqbalJunaid IqbalKamran SadiqSheraz AhmedYael HabermanLee A DensonSyed Asad AliSean R Moore

Published in: The Journal of nutrition (2022)

Dysregulated bile acid metabolism is associated with growth faltering and EED severity in undernourished children. Restoration of intestinal BA homeostasis may offer a novel therapeutic target for undernutrition in children with EED. This trial was registered at clinicaltrials.gov as NCT03588013.

Keyphrases

young adults
clinical trial
randomized controlled trial
gene expression
risk assessment
single cell
genome wide
dna methylation
human health