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Noninferiority Margin Size and Acceptance of Trial Results: Contingent Valuation Survey of Clinician Preferences for Noninferior Mortality.

Sandra PongRobert A FowlerNicholas MitsakakisSrinivas MurthyJeffrey M PernicaElaine GilfoyleAsha BowenPatricia FontelaWinnie SetoMichelle ScienceJames S HutchisonPhilippe JouvetAsgar RishuNick Daneman
Published in: Medical decision making : an international journal of the Society for Medical Decision Making (2022)
Clinicians are more likely to accept shorter treatment durations based on noninferior mortality results when the noninferiority margin is 5% or 10% than if the margin is 20%.However, nearly half of clinicians would still accept shorter-duration treatment as noninferior with margins of 20%.Baseline mortality does not independently predict acceptance of shorter-duration treatment.Contingent valuation is a novel approach to elicit the acceptance of research design parameters from the perspective of endusers of the medical literature.
Keyphrases
  • healthcare
  • palliative care
  • clinical trial
  • risk factors
  • type diabetes
  • randomized controlled trial
  • cross sectional