Is gene expression among women with rheumatoid arthritis dysregulated during a postpartum flare?
Matthew WrightMette K SmedJ Lee NelsonJørn OlsenMerete L HetlandVibeke ZoffmannDamini JawaheerPublished in: Arthritis research & therapy (2021)
The large majority of gene expression changes between T3 and 3 months postpartum among RA women who flared postpartum reflected normal postpartum changes also seen among healthy women. Nonetheless, during a postpartum flare, a set of immune-related genes showed dysregulated expression compared to healthy women and women with RA whose disease activity was low or in remission during the same time frame, while other genes demonstrated significant differences in expression compared to RA pre-pregnancy levels.
Keyphrases
- disease activity
- rheumatoid arthritis
- gene expression
- systemic lupus erythematosus
- ankylosing spondylitis
- rheumatoid arthritis patients
- polycystic ovary syndrome
- pregnancy outcomes
- poor prognosis
- juvenile idiopathic arthritis
- dna methylation
- interstitial lung disease
- type diabetes
- preterm birth
- insulin resistance
- genome wide
- pregnant women
- metabolic syndrome
- breast cancer risk
- genome wide identification
- transcription factor