Bone Marrow Avatars: Mimicking Hematopoiesis in a Dish.
Marta DereckaJohn D CrispinoPublished in: Cancer discovery (2023)
Faithful recapitulation of human bone marrow complexity has been a major challenge for the sci-entific community for many years. In this issue of Cancer Discovery, Khan and colleagues present an improved induced pluripotent stem cell differentiation protocol that generates bone marrow organoids re-creating key characteristics of human marrow. See related article by Khan et al., p. 364 (8).
Keyphrases
- bone marrow
- endothelial cells
- mesenchymal stem cells
- induced pluripotent stem cells
- high glucose
- spinal cord injury
- healthcare
- pluripotent stem cells
- small molecule
- randomized controlled trial
- mental health
- papillary thyroid
- squamous cell carcinoma
- oxidative stress
- drug induced
- squamous cell
- young adults
- hematopoietic stem cell