Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia.

Yang-Yang DingHannah KimKellyn MaddenJoseph P LoftusGregory M ChenDavid Hottman AllenRuitao ZhangJason XuChia-Hui ChenYuxuan HuSarah K TasianKai Tan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Our study represents a powerful conceptual framework for combinatorial drug discovery based on systematic interrogation of synergistic vulnerability pathways with pharmacologic inhibitor validation in preclinical human leukemia models.

Keyphrases

acute lymphoblastic leukemia
combination therapy
drug discovery
network analysis
endothelial cells
allogeneic hematopoietic stem cell transplantation
cancer therapy
copy number
climate change
bone marrow
acute myeloid leukemia
stem cells
gene expression
pluripotent stem cells