Suppression of Hepatic PPARα in Primary Biliary Cholangitis Is Modulated by miR-155.
Monika AdamowiczAgnieszka Kempinska-PodhorodeckaJoanna AbramczykJesus M BanalesPiotr MilkiewiczMałgorzata MilkiewiczPublished in: Cells (2022)
Hepatic PPARα expression is reduced in PBC livers as a likely result of miR-155 overexpression. UDCA effectively reduced both baseline and LPS-induced miR-155 expression, thus preventing the suppression of PPARα.