Human hnRNPA1 reorganizes telomere-bound Replication Protein A.

Sophie L GrangerRicha SharmaVikas KaushikMortezaali Razzaghi Masayoshi Honda Divya S Bhat Marcin W WlodarskiEdwin AntonyMaria Spies

Published in: bioRxiv : the preprint server for biology (2023)

At the single-stranded ends of human telomeres, the heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) binds to and modulates conformational dynamics of the ssDNA binding protein RPA forming a ternary complex which is controlled by TERRA RNA.

Keyphrases

binding protein
endothelial cells
pluripotent stem cells
induced pluripotent stem cells
single molecule
small molecule
molecular dynamics
molecular dynamics simulations
reduced graphene oxide
nucleic acid
protein protein