Maria Spies

Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 26

Top Venues

Nature communications

bioRxiv : the preprint server for biology

NAR cancer

International journal of molecular sciences

University of Iowa

Osaka Daigaku (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Iowa Jul 01 2018

United States

Professor :: Biochemistry and Radiation Oncology

University of Iowa Jun 10 2012 - Jun 30 2018

United States

Associate professor :: Biochemistry

Howard Hughes Medical Institute Sep 01 2009 - Jun 10 2012

United States

Early Career scientist

University of Illinois at Urbana-Champaign Oct 15 2005 - Jun 10 2012

United States

Assistant Professor :: Biochemistry

Education History

Osaka Daigaku Oct 01 1994 - Mar 31 2000

Japan

PHD :: Biological Sciences

Peter the Great St. Petersburg Polytechnic University Sep 01 1994 - Mar 31 1996

Russia

MSC :: Biophysics

Peter the Great St. Petersburg Polytechnic University Sep 01 1990 - Aug 31 1994

Russia

BSC :: Biophysics

Publications

Sarah R Hengel, Katherine G Oppenheimer, Chelsea M Smith, Matthew A Schaich, Hayley L Rein, Julieta Martino, Kristie E Darrah, Maggie Witham, Oluchi C Ezekwenna, Kyle R Burton, Bennett Van Houten, Maria Spies, Kara A Bernstein
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA. Nature communications 15 (1) (2024)
Sarah R Hengel, Katherine G Oppenheimer, Chelsea M Smith, Matthew A Schaich, Hayley L Rein, Julieta Martino, Kristie E Darrah, Maggie Witham, Oluchi C Ezekwenna, Kyle R Burton, Bennett Van Houten, Maria Spies, Kara A Bernstein
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA. Nature communications 15 (1) (2024)
Sarah R Hengel, Katherine G Oppenheimer, Chelsea M Smith, Matthew A Schaich, Hayley L Rein, Julieta Martino, Kristie E Darrah, Maggie Witham, Oluchi C Ezekwenna, Kyle R Burton, Bennett Van Houten, Maria Spies, Kara A Bernstein
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA. Nature communications 15 (1) (2024)
Sarah R Hengel, Katherine G Oppenheimer, Chelsea M Smith, Matthew A Schaich, Hayley L Rein, Julieta Martino, Kristie E Darrah, Maggie Witham, Oluchi C Ezekwenna, Kyle R Burton, Bennett Van Houten, Maria Spies, Kara A Bernstein
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA. Nature communications 15 (1) (2024)
Lisa Hong, Dennis C Braden, Yaoning Zhao, John J Skoko, Fei Chang, Steven R Woodcock, Crystall Uvalle, Allison Casey, Katherine Wood, Sonia R Salvatore, Alparslan Asan, Trey Harkness, Adeola Fagunloye, Mortezaali Razzaghi, Adam Straub, Maria Spies, Daniel D Brown, Adrian V Lee, Francisco Schopfer, Bruce A Freeman, Carola A Neumann
Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies. bioRxiv : the preprint server for biology (2023)
Divya S Bhat, Eva Malacaria, Ludovica Di Biagi, Mortezaali Razzaghi, Masayoshi Honda, Kathryn F Hobbs, Sarah R Hengel, Pietro Pichierri, M Ashley Spies, Maria Spies
Therapeutic disruption of RAD52-ssDNA complexation via novel drug-like inhibitors. NAR cancer 5 (2) (2023)
Khaliunaa Bayanbold, Mekhla Singhania, Melissa A Fath, Charles C Searby, Jeffrey M Stolwijk, John B Henrich, Casey F Pulliam, Joshua D Schoenfeld, Kranti A Mapuskar, Sei Sho, Joseph M Caster, Bryan G Allen, Garry R Buettner, Maria Spies, Prabhat C Goswami, Michael S Petronek, Douglas R Spitz
Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer. Antioxidants (Basel, Switzerland) 12 (11) (2023)
Sophie L Granger, Richa Sharma, Vikas Kaushik, Mortezaali Razzaghi, Masayoshi Honda, Divya S Bhat, Marcin W Wlodarski, Edwin Antony, Maria Spies
Human hnRNPA1 reorganizes telomere-bound Replication Protein A. bioRxiv : the preprint server for biology (2023)
Divya S Bhat, Eva Malacaria, Ludovica Di Biagi, Mortezaali Razzaghi, Masayoshi Honda, Kathryn F Hobbs, Sarah R Hengel, Pietro Pichierri, M Ashley Spies, Maria Spies
Therapeutic disruption of RAD52-ssDNA complexation via novel drug-like inhibitors. NAR cancer 5 (2) (2023)
Paras Gaur, Fletcher E Bain, Masayoshi Honda, Sophie L Granger, Maria Spies
Single-molecule analysis of the improved variants of the G-quadruplex recognition protein G4P. bioRxiv : the preprint server for biology (2023)
Paras Gaur, Fletcher E Bain, Masayoshi Honda, Sophie L Granger, Maria Spies
Single-Molecule Analysis of the Improved Variants of the G-Quadruplex Recognition Protein G4P. International journal of molecular sciences 24 (12) (2023)
Paras Gaur, Fletcher E Bain, Masayoshi Honda, Sophie L Granger, Maria Spies
Single-Molecule Analysis of the Improved Variants of the G-Quadruplex Recognition Protein G4P. International journal of molecular sciences 24 (12) (2023)
Divya S Bhat, Eva Malacaria, Ludovica Di Biagi, Mortezaali Razzaghi, Masayoshi Honda, Kathryn F Hobbs, Sarah R Hengel, Pietro Pichierri, M Ashley Spies, Maria Spies
Therapeutic disruption of RAD52-ssDNA complexation via novel drug-like inhibitors. NAR cancer 5 (2) (2023)
Jiao Mo, Nicholas Borcherding, Sung Jo, Tanzia Islam Tithi, Edward Cho, Kailey E Cash, Masayoshi Honda, Lei Wang, Kawther K Ahmed, Ronald Weigel, Maria Spies, Ryan Kolb, Weizhou Zhang
Contrasting roles of different mismatch repair proteins in basal-like breast cancer. bioRxiv : the preprint server for biology (2023)
Masayoshi Honda, Mortezaali Razzaghi, Paras Gaur, Eva Malacaria, Ludovica Di Biagi, Francesca Antonella Aiello, Emeleeta A Paintsil, Andrew Stanfield, Bailey J Deppe, Lokesh Gakhar, Nicholas J Schnicker, M Ashley Spies, Pietro Pichierri, Maria Spies
Human RAD52 double-ring remodels replication forks restricting fork reversal. bioRxiv : the preprint server for biology (2023)
Paras Gaur, Fletcher E Bain, Masayoshi Honda, Sophie L Granger, Maria Spies
Single-Molecule Analysis of the Improved Variants of the G-Quadruplex Recognition Protein G4P. International journal of molecular sciences 24 (12) (2023)
Joseph Tibbs, Mohamed Ghoneim, Colleen C Caldwell, Troy Buzynski, Wayne Bowie, Elizabeth M Boehm, M Todd Washington, S M Ali Tabei, Maria Spies
KERA: analysis tool for multi-process, multi-state single-molecule data. Nucleic acids research 49 (9) (2021)
Richa Sharma, Sushree S Sahoo, Masayoshi Honda, Sophie L Granger, Charnise Goodings, Louis Sanchez, Axel Künstner, Hauke Busch, Fabian Beier, Shondra M Pruett-Miller, Marcus Valentine, Alfonso Gonzalez Fernandez, Ti-Cheng Chang, Vincent Geli, Dimitri Churikov, Sandrine Hirschi, Victor B Pastor, Melanie Börries, Melchior Lauten, Charikleia Kelaidi, Marcin W Wlodarski, Megan Anne Cooper, Sarah K Nicholas, Jill Anne Rosenfeld, Sophia Polychronopoulou, Caroline Kannengiesser, Carole Saintomé, Charlotte M Niemeyer, Patrick Revy, Marc S Wold, Maria Spies, Miriam Erlacher, Stephane Coulon
Gain-of-Function Mutations in RPA1 Cause a Syndrome with Short Telomeres and Somatic Genetic Rescue. Blood (2021)
Barbara Stekas, Steve Yeo, Alice Troitskaia, Masayoshi Honda, Sei Sho, Maria Spies, Yann R Chemla
Switch-like control of helicase processivity by single-stranded DNA binding protein. eLife 10 (2021)
Shyamal Subramanyam, Maria Spies
RAD51 discrimination between single- and double-strand DNA: a matter of flexibility and enthalpy. The EMBO journal 39 (7) (2020)
Colleen C Caldwell, Maria Spies
Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair. Critical reviews in biochemistry and molecular biology 55 (5) (2020)
Nilisha Pokhrel, Colleen C Caldwell, Elliot I Corless, Emma A Tillison, Joseph Tibbs, Nina Jocic, S M Ali Tabei, Marc S Wold, Maria Spies, Edwin Antony
Dynamics and selective remodeling of the DNA-binding domains of RPA. Nature structural & molecular biology 26 (2) (2019)
Luke A Yates, Ricardo J Aramayo, Nilisha Pokhrel, Colleen C Caldwell, Joshua A Kaplan, Rajika L Perera, Maria Spies, Edwin Antony, Xiaodong Zhang
A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA. Nature communications 9 (1) (2018)
Colleen C Caldwell, Maria Spies
Helicase SPRNTing through the nanopore. Proceedings of the National Academy of Sciences of the United States of America 114 (45) (2017)
Shyamal Subramanyam, Mohammed Ismail, Ipshita Bhattacharya, Maria Spies
Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics. Proceedings of the National Academy of Sciences of the United States of America 113 (41) (2016)
Sarah R Hengel, Eva Malacaria, Laura Folly da Silva Constantino, Fletcher E Bain, Andrea Diaz, Brandon G Koch, Liping Yu, Meng Wu, Pietro Pichierri, M Ashley Spies, Maria Spies
Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells. eLife 5 (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Maria Spies