Hydroxychloroquine attenuates neuroinflammation following traumatic brain injury by regulating the TLR4/NF-κB signaling pathway.
Jian HuXue WangXiongjian ChenYani FangKun ChenWenshuo PengZhengyi WangKaiming GuoXianxi TanFei LiangLi LinYe XiongPublished in: Journal of neuroinflammation (2022)
HCQ reduced proinflammatory cytokine expression, and the underlying mechanism may involve suppressing the TLR4/NF-κB signaling pathway, suggesting that HCQ is a potential therapeutic agent for TBI treatment.
Keyphrases
- signaling pathway
- traumatic brain injury
- pi k akt
- toll like receptor
- inflammatory response
- induced apoptosis
- epithelial mesenchymal transition
- lps induced
- immune response
- poor prognosis
- nuclear factor
- severe traumatic brain injury
- lipopolysaccharide induced
- binding protein
- oxidative stress
- replacement therapy
- mild traumatic brain injury