Oleic Acid Protects Against Insulin Resistance by Regulating the Genes Related to the PI3K Signaling Pathway.
Carlos Lopez-GomezConcepción Santiago-FernándezSara García-SerranoEva García-EscobarCarolina Gutiérrez-RepisoCristina Rodríguez-DíazAilec Ho-PlágaroFlores Martín-ReyesLourdes Garrido-SánchezSergio ValdesAlberto Rodríguez-CañeteFrancisca Rodríguez-PachecoEduardo Garcia-FuentesPublished in: Journal of clinical medicine (2020)
Our in vitro results suggest a detrimental role of palmitic acid on the expression of gene related to insulin signaling pathway, with oleic acid being the one with the higher and more beneficial effects. DHA had a slight beneficial effect. Fatty acid-induced regulation of genes related to the IRS1/PI3K pathway may be a novel mechanism by which fatty acids regulate insulin sensitivity in visceral adipocytes.
Keyphrases
- signaling pathway
- insulin resistance
- fatty acid
- genome wide
- type diabetes
- adipose tissue
- pi k akt
- poor prognosis
- genome wide identification
- metabolic syndrome
- epithelial mesenchymal transition
- skeletal muscle
- cell proliferation
- oxidative stress
- polycystic ovary syndrome
- glycemic control
- genome wide analysis
- copy number
- long non coding rna
- endoplasmic reticulum stress
- high fat diet induced