Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer.
Asunción Martín-RuizLaura PeñaAlfredo González-GilLucía Teresa Díez-CórdovaSara CáceresJuan Carlos IlleraPublished in: BMC cancer (2018)
Our data reveal for the first time that the ingestion of indole-3-carbinol, as administered, diminishes proliferation and increases apoptosis of tumor cells in an experimental model of inflammatory breast cancer, although this effect could not be enough to avoid the appearance of tumor embolization and metastasis. Future clinical trials will be needed to clarify the usefulness of indole-3-carbinol in this cancer and to understand the molecular mechanisms involved.
Keyphrases
- oxidative stress
- clinical trial
- papillary thyroid
- poor prognosis
- signaling pathway
- cell death
- electronic health record
- endoplasmic reticulum stress
- squamous cell
- genome wide
- single cell
- cell cycle arrest
- childhood cancer
- high fat diet induced
- randomized controlled trial
- big data
- adipose tissue
- dna methylation
- squamous cell carcinoma
- long non coding rna
- insulin resistance
- phase ii