Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trial.
Guylaine LabroFlorence TubachLisa BelinJean-Louis DubostDavid OsmanGrégoire MullerJean-Pierre QuenotDaniel Da SilvaJonathan ZarkaMatthieu TurpinJulien MayauxChristian LamerDenis DoyenGuillaume ChevrelGaétan PlantefeveSophie DemeretGaël PitonCyril ManzonEvelina OchinRaphael GaillardBertrand DautzenbergMathieu BaldaciniSaid LebbahMakoto MiyaraMarc Pineton de ChambrunZahir AmouraAlain Combesnull nullPublished in: Intensive care medicine (2022)
In patients having developed severe COVID-19 pneumonia requiring invasive mechanical ventilation, transdermal nicotine did not significantly reduce day-28 mortality. There is no indication to use nicotine in this situation.
Keyphrases
- mechanical ventilation
- end stage renal disease
- double blind
- acute respiratory distress syndrome
- coronavirus disease
- placebo controlled
- intensive care unit
- chronic kidney disease
- ejection fraction
- sars cov
- study protocol
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- smoking cessation
- respiratory failure
- phase iii
- type diabetes
- early onset
- randomized controlled trial
- cardiovascular disease
- cardiovascular events
- radiation therapy
- patient reported outcomes
- risk factors
- open label
- patient reported
- cross sectional