Longer interval between maternal RSV vaccination and birth increases placental transfer efficiency.
Ms Olyvia J JassetPaola Andrea Lopez ZapanaZeynep BahadirLydia L ShookMs Maria DennisMs Emily GilbertMs Zhaojing Ariel LiuMs Rachel V YingerMs Caroline BaldMs Caroline G BradfordMs Alexa H SilfenSabra L KleinAndrew S PekoszSallie PermarLiza KonnikovaLael M YonkerDouglas A LauffenburgerAshley NelsonMichal A ElovitzAndrea G EdlowPublished in: medRxiv : the preprint server for health sciences (2024)
Vaccine administration earlier in the approved 32-36 week window (at least 5 weeks prior to delivery) results in the highest transplacental transfer of maternal antibodies to the neonate. These results should inform the counseling of pregnant individuals on optimal vaccination timing.