Does volatile sedation with sevoflurane allow spontaneous breathing during prolonged prone positioning in intubated ARDS patients? A retrospective observational feasibility trial.
Jascha HeiderJoachim BansbachKai KaufmannSebastian HeinrichTorsten LoopJohannes KalbhennPublished in: Annals of intensive care (2019)
Pressure-supported spontaneous breathing during prolonged prone positioning in intubated ARDS patients with or without ECMO can be achieved during volatile sedation with sevoflurane. This finding may provide a basis upon which to question the latest dogma in ARDS treatment. Our concept must be further investigated and compared to controlled ventilation with regard to driving pressure, lung-protective parameters, muscle weakness and mortality before it can be routinely applied.
Keyphrases
- mechanical ventilation
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- respiratory failure
- end stage renal disease
- intensive care unit
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- clinical trial
- prognostic factors
- study protocol
- cardiovascular events
- skeletal muscle
- randomized controlled trial
- gas chromatography
- risk factors
- phase iii
- cross sectional
- mass spectrometry
- atomic force microscopy
- high resolution
- open label