Tumor cell SYK expression modulates the tumor immune microenvironment composition in human cancer via TNF-α dependent signaling.

Adam Aguirre-DuclerNicole GianinoFranz Villaroel-Espindola Shruti S DesaiDaiwei TangHongyu ZhaoKonstantinos SyrigosWilliam L TrepicchioKaruppiah KannanRichard C GregoryKurt A Schalper

Published in: Journal for immunotherapy of cancer (2022)

Together, our results establish the immunomodulatory role of SYK expression in human solid tumors. This information could be used to develop novel biomarkers and/or therapeutic strategies.

Keyphrases

endothelial cells
poor prognosis
induced pluripotent stem cells
tyrosine kinase
rheumatoid arthritis
pluripotent stem cells
stem cells
single cell
papillary thyroid
cell therapy
bone marrow