Gut Microbiota-Derived Indole Derivatives Alleviate Neurodegeneration in Aging through Activating GPR30/AMPK/SIRT1 Pathway.

Jia YinYunhui ZhangXiaoxia LiuWanhua LiYaozhong HuBowei ZhangShuo Wang

Published in: Molecular nutrition & food research (2023)

The findings reveal that Trp metabolites significantly improve neurodegeneration via GPR30/AMPK/SIRT1 pathway in aging process. This study provides the potential novel intervention strategy and target to prevent the neurodegeneration.

Keyphrases

skeletal muscle
randomized controlled trial
oxidative stress
fatty acid
ischemia reperfusion injury
ms ms
signaling pathway
genome wide
gene expression
single cell