Pathway attenuation of fatty acid beta-oxidation in the skeletal muscle of a type 2 diabetic mouse model.
Yang ZhouYifan TanGuixue HouYan RenYamei DengKeqiang YanYue ZhangLiang LinXiaomin LouSiqi LiuPublished in: Rapid communications in mass spectrometry : RCM (2021)
The findings of lower abundance of ACAD9 and CPT1B, reduced activity of the mFAO pathway in vitro and decreased acylcarnitines in vivo firmly support that the mFAO pathway in the skeletal muscle of diabetic mice is attenuated, possibly resulting in cell/tissue dysfunction in diabetes.