Exosomes Derived from Bone Mesenchymal Stem Cells with the Stimulation of Fe3O4 Nanoparticles and Static Magnetic Field Enhance Wound Healing Through Upregulated miR-21-5p.

Di WuLin KangJingjing TianYuanhao WuJieying LiuZhengyao LiXiangdong WuYue HuangBo GaoHai WangZhihong WuGuixing Qiu

Published in: International journal of nanomedicine (2020)

Mag-BMSC-Exos can further enhance wound healing than BMSC-Exos by improving angiogenesis and fibroblast function, and miR-21-5p upregulation in mag-BMSC-Exos might be the potential mechanism. This work offers an effective and promising protocol to improve wound healing in clinic.

Keyphrases

wound healing
mesenchymal stem cells
umbilical cord
randomized controlled trial
primary care
bone marrow
cell proliferation
poor prognosis
bone mineral density
signaling pathway
cell therapy
risk assessment
soft tissue
human health