Downregulation of FABP5 Suppresses the Proliferation and Induces the Apoptosis of Gastric Cancer Cells Through the Hippo Signaling Pathway.
Wendong WangZhenzhen LiuXin ChenYongqu LuBingyan WangFei LiSiyi LuXin ZhouPublished in: DNA and cell biology (2021)
Fatty acid binding protein 5 (FABP5) has been reported to play an important role in various cancers. We found that high FABP5 expression was associated with poor histological differentiation and vascular invasion. High FABP5 expression indicated a poor prognosis. Downregulation of FABP5 suppressed cell proliferation, cell migration and invasion, and induced cell apoptosis. Bioinformatic analysis revealed that the Hippo signaling pathway was related to FABP5. We found that overexpression of yes-associated protein 1 (YAP1) could partially reverse the effect of FABP5 knockdown on growth and apoptosis. The FABP5 inhibitor SBFI-26 suppressed the proliferation and promoted the apoptosis of gastric cancer (GC) cells and interfered with the Hippo signaling pathway by inhibiting YAP1. Our data suggested that FABP5 might act as a potential target associated with the Hippo signaling pathway for GC treatment.
Keyphrases
- binding protein
- signaling pathway
- pi k akt
- cell cycle arrest
- poor prognosis
- induced apoptosis
- cell proliferation
- epithelial mesenchymal transition
- oxidative stress
- endoplasmic reticulum stress
- long non coding rna
- cell death
- fatty acid
- machine learning
- cell therapy
- diabetic rats
- bone marrow
- big data
- young adults
- mesenchymal stem cells
- mass spectrometry
- high resolution
- gas chromatography
- high glucose